Serologic and virologic tests

最後更新於 Dec 31, 2023 🪚 編輯原始文件

• anti-HBs 跟 HBsAg 兩個只能有一個存在
• Precore mutant: HBeAg not made, but anti-HBe can develop due to → x-reactivity w/ HBcAg; a/w ↑ HBV DNA
• HBsAg: appears before sx; used to → screen blood donors; persists >6 mo = chronic HBV
• HBeAg: evidence of viral replication and ↑ infectivity
• IgM anti-HBc: 1st Ab to → appear; indicates acute infection window period = HBsAg becomes ⊖, anti-HBs not yet ⊕, anti-HBc only clue to → infxn
• IgG anti-HBc: indicates previous (HBsAg ⊖) or ongoing (HBsAg ⊕) HBV infection
• anti-HBe: indicates waning viral replication, ↓ infectivity
• anti-HBs: indicates resolution of acute disease & immunity (sole marker after vaccination)
• HBV DNA: presence in serum correlates w/ active viral replication in liver

see also 👉 Laboratory Abnormalities of HBV Clinical Presentation

→ 急性感染後恢復者: 感染 B 型肝炎病毒約半年後：HBsAg 消失、Anti-HBs 出現

• HBsAg + : 1.好肝帶原者; 2.壞肝 cHBV
• HBsAg - : 見下表 hint: 中過 = 中 = Core = Center

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if anti-HBc = TRUE: check(anti-HBe, HBeAg, HBV_DNA)