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🌱 來自: unique subtypes of MDS

5q-syn as a unique subtypes of MDS

Characterized by progressive anemia, preserved/elevated plt count, & del(5q) as sole cytogenetic abnormality or w/ 1 other except del7q or -7 Female predominance; classically benign course w/ low risk of transformation to AML In addition to dyserythropoiesis, micromegakaryocytes present in most cases (80%) Excellent RR to lenalidomide, w/ most pts achieving red-cell transfusion-independence & some w/ complete cytogenetic response (NEJM 2006;355:1456)