Info
🌱 來自: Metastatic Colon Cancer
TAS-102
Trifluridine and Tipiracil
- tri_
FLUridine and tiPI_racil - Lonsurf
- Severe and life-threatening myelosuppression (anemia, neutropenia, thrombocytopenia), including febrile neutropenia and fatal neutropenia, reported. -0Adverse effects and laboratory abnormalities reported in ≥10% of patients receiving trifluridine/tipiracil: Anemia, neutropenia, fatigue/asthenia, nausea, thrombocytopenia, decreased appetite, diarrhea, vomiting, pyrexia. [ref]
Monitor CBCs prior to each cycle, on day 15 of each cycle, and as clinically indicated. [ref] Do not initiate cycle until ANC ≥1500/mm3 and platelet count ≥75,000/mm3. [ref] If neutropenia or thrombocytopenia occurs, interrupt therapy, reduce dosage, or permanently discontinue drug. [ref]
