Granulomatosis with polyangiitis
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GPA, formerly Wegener’s granulomatosis
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Predominant type; can see either type (NEJM 2012;367:214);
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Necrotizing granulomatous systemic vasculitis frequently affecting upper respiratory tract (nose, sinuses) in addition to kidneys, lower resp tract (lungs), and other organs
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Epi: incidence 12/million/y; any age but ↑ in young/middle-aged adults; ♂=♀