Amiodarone
300 mg over 1 h then 10-50 mg/h X 24h
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150 mg/3 mL
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loading infusion：150 mg in 100 mL over 10 min；
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followed by 900 mg in 500 mL over 6 hr
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MAX initial infusion rate 30 mg/min。
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5-7 mg/kg /V over
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30-60 mg/min,
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10-g load
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200-400 mg qd
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(most effective
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AAD for SR)
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QT, TdP rare. Often delay tO
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convert. Poss.pulm, liver,
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thyroid tox. 个 INR w/ warfarin.
side effects
- Thyroid: This can cause overactive or underactive (most common) thyroid disease
- Liver: This causes elevated enzymes in the blood from damaged liver cells and leads to symptoms like nausea and jaundice.
- Lung: This results in lung scarring and other serious lung conditions.
- Heart: This leads to heart conduction system abnormalities and dangerously low heart rates.
- Neurological system: This causes peripheral neuropathy and cognitive impairment.
- Skin: This leads to blue skin discoloration and sensitivity to the sun.