Etiologies of Classic FUO

Infection as Etiologies of Classic FUO

~30%

Connective tissue disease as Etiologies of Classic FUO

~30%

Neoplasm Etiologies of Classic FUO

~20%

注意

Q fever and Whipple’s disease (Tropheryma whipplei infection) are quite rare but should always be kept in mind as a cause of FUO since the presenting symptoms can be nonspecific.

Misc ~20%

• Drug fever
• Factitious disorder
• venous thromboembolism
• hematoma
• Thyroiditis or thyroid storm,
• adrenal insufficiency, pheochromocytoma
• Granulomatous hepatitis (many causes),
• sarcoidosis, Kikuchi’s, Behçet’s syndrome
• Familial Mediterranean fever
• other defects in innate immunity