Info
Genetics of chronic lymphocytic leukemia
unfavorable;
- del 11q22-23
- & del(17p)
- CD38,
- Zap 70,
- CD49d,
- del(11q),
- del(17p)/TP53,
- ≥3 chromosome
neutral
- trisomy 12
favorable.
del 13q14 and mut IGHV
Nine significantly mutated genes
- TP53,
- NOTCH1,
- MYD88, and
- SF3B1.
- Key role for spliceosome mutations
- (NEJM 2011;365:2497; JCI 2012;122:3432).