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🌱來自: Neutropenia-Febrile-High-Risk

Comments of Neutropenia-Febrile-High-Risk

• Duration of empiric therapy:  when clinically recovered and afebrile for 72 hrs
  • In a multicenter randomized study, control patients continued empiric antibiotic therapy until the absolute neutrophil count was ≥ 0.5 x 10⁹ cells /L; the experimental group discontinued empiric antibiotics if clinically recovered and afebrile for 72 hrs. Early discontinuation was as safe as continuing empiric antibiotic until the marrow had recovered ([Lancet Hematol  2017;4:e573][22]).
  • A retrospective study supported the recommendations of the [Fourth European Conference on Infections in Leukaemia][23] which includes a strategy of stopping empiric antibacterials within 48-72h after resolution of fever ([Open Forum Infect Dis 2021][24])[][25]
• Addition of granulocyte colony stimulating factors during neutropenic fever can be considered in patients at high-risk for infectious complications.
• Recommendations above are based on the IDSA Practice Guidelines ([Clin Infect Dis 52:427, 2011][26]) and [National Comprehensive Cancer Network Guidelines][27] on Prevention and Treatment of Cancer-Related Infections, Version.2019