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🌱來自: renal-cell-carcinoma

Hereditary RCC and germline testing

There are several RCC-assoc genetic CA syn incl. VHL, HLRCC (FH gene), BAP1 tumor predisposition syn, Birt-Hogg-Dubé (FLCN gene), among others Consider any of the following for Hereditary RCC gene panel testing & CA Genetics referral:

Siblings

• Epidemiology
• Histology and molecular biology
• Hereditary RCC and germline testing
• Clinical presentation
• Staging (TNM classification) and prognosis
• Treatment principles
• Systemic therapy for metastatic clear cell RCC
• Second-line therapies
• Combined-modality therapies
• Tyrosine kinase inhibitors
• Immunotherapies
• mTOR inhibitors
• Non-clear cell histology