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Spondyloarthritis (SpA) Epidemiology and Key Presentation Features

DiseaseEpidemiology
Ankylosing spondylitis (AS)♂:♀ = 3:1; onset in teens to mid-20s (rare after 40 y)
Psoriatic arthritis (PsA)♂ = ♀; peak incidence 45-54 y; seen in 20-30% of Pts w/ psoriasis
Reactive arthritis (ReA)♂ >> ♀; 20-40 y; 10-30 d after GI or GU infxn* in genetically susceptible host
IBD-associated arthritis♂ = ♀; seen in 20% of IBD Pts; Crohn’s >UC

DiseaseKey Features
Ankylosing spondylitis (AS)Progressive limitation of spinal motion, a.m. stiffness, buttock pain, “bamboo spine,” ⊕ Schober test
Psoriatic arthritis (PsA)In 13-17% arthritis precedes skin findings by yrs; does not correlate with psoriasis activity; a/w HIV
Reactive arthritis (ReA)Arthritis, urethritis, and conjunctivitis. Most resolve w/in 12 mo.
IBD-associated arthritisType I <5 joints: correlates w/ IBD activ. Type II >5 joints or axial disease: does not correlate w/ IBD activity