Duration of full-intensity anticoagulation-venous thromboembolism

• Superficial venous thrombosis: 4 wk

• 1st prox DVT or PE 2° reversible/time-limited risk factor or distal DVT:

  • 3–6 mo

• 1st unprovoked prox DVT/PE: ≥3 mo, then reassess; benefit to prolonged Rx. Consider clot, bleed risk, Pt preference, and intensity of Rx when crafting strategy.

• 2nd VTE event or cancer: indefinite (or until cancer cured) (NEJM 2003;348:1425)