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etiologies of thrombocytosis🚧 施工中
etiologies of thrombocytosis
• 1° = ET or other MPN; myelodysplastic syndromes (5q-syndrome); RARS-T
• 2° = reactive thrombocytosis: inflammation (RA, IBD, vasculitis), infection, trauma, acute bleed, iron deficiency, postsplenectomy, neoplasms (eg, Hodgkin lymphoma)
• Of patients with plt >1,000,000/µL, <1 in 6 will have ET
Clinical manifestations (also see “Polycythemia Vera”)
• Thrombosis with erythromelalgia (risk of thrombosis highest in Pts with leukocytosis), bleeding (acquired vWD), pruritus; mild splenomegaly; migraine, TIA; early fetal loss