Info

🌱 來自：Monoclonal Antibodies

Avelumab

• Mechanism: Binds to PD-L1
• Dosing:
  • 800 mg or 10 mg/kg every 2 wks; consider holding tx if renal or hepatic toxicity develop
• PK/PD: T1/2 ∼6.1 d; 1° elimination is proteolytic degradation
• AEs:
  • Immune-mediated tox,
  • diarrhea,
  • hepatitis B reactivation,
  • infusion rxn,
  • skin rash,
  • fatigue,
  • leukopenia,
  • ↑ liver enzymes,
  • arthralgia
• DDI:
  • No known pathways of metabolism; Avoid corticosteroids since it may diminish the therapeutic effect of immune checkpoint inhibitors
• Clinical pearls:
• Tx immune-related tox w/ steroids (prednisone 1-2 mg/kg/d)