Aplastic anemia

(stem cell failure) (NEJM 2015;373:35)

Epidemiology

• 2-5 cases/106/y
• biphasic (major peak in adolescents, 2nd peak in elderly)

Diagnosis

pancytopenia w/

• ↓ retics,

• BM bx w/ hypocellularity, usually nl cytogenetics

• Etiologies-Aplastic anemia

• classification of aplastic anemia and single cytopenias

• Treatment and prognosis-Aplastic anemia

• treatement of refractory aplastic anemia 󰒗

難治性疾病 (refractory DISEASE)