Approach to glomerulonephritis based on immunofluorescence pattern

看圖說故事

Glomerulonephritis

ANCA

ANCA 🀄 Vasculitis : (pauci-immune)

• c-ANCA :
  • granulomatosis w polyangiitis
• p-ANCA :
  • eosinophilic granulomatosis with polyangiitis
  • microscopic polyangiitis

anti-GBM

Anti-GBM Disease : (linear IF)

• lung hemorrhage : Goodpasture’s
• Anti-glomerular basement membrane

👇complement

Immune Complex Disease : (granular IF)

• 👇C3

  • PSGN, MPGN
  • SLE, IE
  • Cryoglobulinemia

• 👌C3

  • IgA/Henoch-Schönlein purpura
  • Fibrillary GN