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AE_CDK46

Abemaciclib:200-150mg BID, AEs such as diarrhea (80%), neutropenia, anemia, fatigue, nausea, and alopecia. Monitor CBC and LFTs on D1 and D14 of first 2 cycles and then on D1 for 4 cycles and periodically. Palbociclib:125mg, AEs such as neutropenia, anemia, fatigue, nausea, alopecia, and diarrhea. Monitor CBC and LFTs on D1 and D14 of first 2 cycles and then on D1 for 4 cycles and periodically. Ribociclib: 600mg(#3 QD), AEs such as neutropenia, anemia, fatigue, nausea, alopecia, diarrhea, and QTc prolong. Monitor CBC and LFTs and on D1 and D14 of first 2 cycles and then on D1 for 4 cycles and periodically. ECG as baseline and D14 and then on D1 of 2nd cycle.

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