Causes of Hemolytic Anemia by Mechanism
(Lancet 2000;355:1169 & 1260)
Intrinsic
- G6PD ❌
- Hemoglobinopathies: Sickle cell anemia, thalassemias
- Membrane abnormalities: Hereditary spherocytosis
- PNH, spur cell anemia in liver
Extrinsic-Acquired
- Immune-mediated Autoimmune; drug-induced, tx rxn
- Traumatic MAHA; prostheses (valves, TIPS)
- Direct infections, toxins Malaria, babesiosis; snake & spider venoms; Wilson’s; hypotonic infusions
- Entrapment Hypersplenism