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Staging of HBV Clinical Presentation

  • Current treatment recommendations depend, in part, on the amount of liver fibrosis and hepatic inflammation.
  • Liver biopsy is → the gold standard.
  • Transient elastography (Fibroscan) is → an acceptable alternative to liver biopsy in most cases.
  • Inflammation and fibrosis. Battery of enzymes and serum proteins are used as a surrogate marker of hepatic inflammation and fibrosis. One example is → the Fibrosure Index. Corrleation with liver biopsy fibrosis is → shown in the Figure. Accuracy of Fibrosure result is → best at ↣ the lower (<0.2) or higher (>0.8) values.

Figure: 🏞️