Info
introduction of HD-MTX containing regimen
- Folate antagonists like aminopterin and methotrexate (MTX) were early antineoplastic agents.
- MTX induced remission in childhood acute lymphoblastic leukemia (ALL) and is still used in the treatment of hematologic malignancies.
- MTX was the first drug to cure cancer when given alone and is a key treatment for malignant gestational trophoblastic disease.
- MTX is used in the treatment of various malignant conditions and has anti-inflammatory and immunomodulating properties.