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🌱 來自: calcium pyrophosphate dihydrate - cppd - deposition disease

Clinical manifestations of CPPD

• Chondrocalcinosis:
  • Chondrocalcinosis 是: 一種關節疾病，其中關節軟骨中積聚了鈣鹽結晶。
  • calcification of cartilage,
  • resulting from CPPD crystal deposition in articular cartilage,
  • fibrocartilage,
  • or menisci
• ↑ incidence w/ age; can be asymptomatic; chondrocalcinosis in 20% >60 y at ↣ autopsy
• Pseudogout:
  • acute CPPD crystal-induced mono- or asymmetric oligoarticular arthritis, indistinguishable from gout except through synovial fluid exam for crystals
  • location:
    • knees,
    • wrists,
    • and MCP joints; rarely,
    • axial (eg,
    • crowned dens syndrome due to CPPD deposition at ↣ C1-C2)
  • precipitants:
    • surgery,
    • trauma,
    • or severe illness
• Chronic forms:
  • “pseudo-RA” and pyrophosphate arthropathy (resembles OA, can involve axial skeleton)