Workup-glomerulonephritis

(JAMA 2017;318:1276)

• Acute GN/RPGN ± lung hemorrhage is an emergency → requires early Dx and Rx

• UA + sediment (dysmorphic RBCs) ✓ ANCA, anti-GBM, C3/C4, SPEP, serum FLC

• Depending on hx: ANA, anti-dsDNA/Sm, RF, Hep B&C, HIV, ASLO, BCx, cryocrit, skin bx

• Consider GN mimics: thrombotic microangiopathies (qv), myeloma, AIN, cholesterol emboli

• Renal biopsy with immunofluorescence (IF) + electron microscopy (EM)