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Venous Thromboembolism and Cancer
Venous Thromboembolism and Cancer | Circulation
Pathophysiological changes that favor thrombosis in patients with cancer include
- platelet activation
- direct factor X activation,
- decreased hepatic anticoagulant synthesis
- reduced hepatic clearance of coagulation factors
- and autoimmune phenomena such as the development of antiphospholipid antibodies
Most patients with active cancer have evidence of chronic systemic coagulation activation, such as elevated plasma d-dimer levels
central role of tissue factor in tumor progression and thrombosis