Inherited Hypercoagulable States

Factor V Leiden

• 3–7%
• 2.65
• Activated protein C (APC) resistance

Prothrombin mutation

• 2%
• 1.45
• G20210A → ↑ prothrombin level

Hyperhomocysteinemia

• 5–10%
• Inherited or acquired (vitamin defic., hypothyroid, renal insufficiency)

Protein C deficiency

• 0.02–0.05%
• 2.8
• Warfarin-induced skin necrosis risk

Protein S deficiency

• 0.01–1%
• 2.8

Antithrombin III def.

• 0.04%
• 2.8
• May be heparin resistant

Relative risk of recurrent VTE compared to patient w/o respective thrombophilia (JAMA 2009;301:2472)