Platelets-transfusion

platelet disorders

For plts <10k (NEJM 2010;362:600) due to chemo/abx. If <20k or if <50k w/ active bleeding.

Variable pre-procedure.

100k for neurosurgery.

1 U

→ ↑ plt ~30–60k.

Single donor plt apheresis

↓ alloimmunization.

Contraindic:

TTP/HUS, HELLP, HIT.

Refractory if ↑ <5k 30–60′ post-plts.

• Suggests consumption such as
  • ITP, DIC, or alloimmunization
    • → trial ABO-matched plts & give more.
      • If still refractory
        • ✓ panel reactive Abs
          • to assess utility of HLA-matched plts.