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🌱 created from: ck_7_and_ck_20

gcdfp-15

Gross cystic disease fluid protein 15 (GCDFP-15)

Uses by pathologists

• Confirming apocrine differentiation in breast and salivary gland lesions (Virchows Arch 2022;480:177)
• Confirming breast or salivary gland primary in metastatic carcinomas (J Mol Pathol 2022;3:219, Semin Diagn Pathol 2022;39:313)
  • Less sensitive than GATA3 and mammaglobin for hormone receptor positive breast cancers
  • Less sensitive than SOX10 for hormone receptor negative breast cancers
  • Less sensitive than TRPS1 for hormone receptor positive, nonapocrine HER2 positive and triple negative breast cancers
• Diagnosis of salivary gland carcinomas including salivary duct carcinoma and acinic cell carcinoma
• Differentiating primary extramammary Paget disease (positive) from secondary extramammary Paget disease (negative) (Arch Pathol Lab Med

Pathology Outlines - Gross cystic disease fluid protein 15 (GCDFP-15)