Info

🌱 來自: treatment of multiple myeloma (MM)

If transplant eligible-of-treatment of multiple myeloma

• after induction chemo
• then high-dose melphalan + auto-HSCT.
• Not curative, but ↑ progression-free survival (PFS) vs. chemo alone (NEJM 2014;371:895, Lancet Onc 2015;16:1617).
• Offer if good perf.
• status & no prohibitive comorbid.
• Maint Rx w/ R improves PFS/OS (NEJM 2014;371:10).
• Timing of HSCT (upfront vs. relapse) debatable.