Clinical manifestations-Cushing’s Syndrome

• Nonspecific:
  • glucose intolerance or DM,
  • HTN,
  • obesity,
  • oligo- or amenorrhea,
  • osteoporosis
• More specific:
  • central obesity w/ extremity wasting,
  • dorsocervical fat pads,
  • spont. bruising
• Most specific:
  • proximal myopathy,
  • rounded facies,
  • facial plethora,
  • wide purple striae
• Other:
  • depression,
  • insomnia,
  • psychosis,
  • impaired cognition,
  • hypokalemia,
  • acne,
  • hirsutism,
  • hyperpigmentation (if ↑ ACTH),
  • fungal skin infxns,
  • nephrolithiasis,
  • polyuria