Info

🌱 來自: multiple myeloma (MM)

multiple myeloma staging systems

• Durie-Salmon Staging System DSS
• Revised International Staging System (R-ISS)

multiple myeloma staging systems

(OS does not account for cytogenetics)

ISS Criteria Durie-Salmon (DS) Criteria ISS Median OS

I

β2M <3.5 mg/L and albumin >3.5 g/dL

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All: Hb >10 g/dL; Ca ≤12 mg/dL; 0–1 lytic bone lesions; IgG <5 g/dL or IgA <3 g/dL or urine light chain <4 g/24 h

62 mo

II

Fulfilling criteria for neither I nor III

44 mo

III

β2M >5.5 mg/L

Any: Hb <8.5 g/dL; Ca >12 mg/dL; >5 lytic bone lesions; IgG >7 g/dL or IgA >5 g/dL or urine light chain >12 g/24 h

29 mo (30 mo if Cr <2 mg/dL; 15 mo if Cr ≥2 mg/dL) *Consider R-ISS incl chrom abnl & LDH (JCO 2005;23:3412 & 2015;61:2267).