NOTE

🌱 created from: immune_complex_(ic)–associated_small-vessel_vasculitis

cryoglobulinemic_vasculitis

(Lancet 2012;379:348; Nat Rev Dis Primers 2018;4:11)

• Cryoglobulins: proteins that precipitate from serum or plasma on exposure to cold and redissolve on rewarming, characterized by their composition; a/w chronic immune stimulation and/or lymphoproliferation
• Distinguish from cryofibrinogenemia = proteins (eg, fibrin, fibrinogen) that precipitate only from plasma; found in autoimmune dis, malignancies, infxns; unclear clinical significance