Clinical manifestations of Cryoglobulinemic vasculitis

Type I

hyperviscosity (cold worsens sx) → HA, visual Δ, livedo, digital ischemia

Type II/III

vasculitis (not affected by cold) → fever, derm (54–80%; purpura, livedo reticularis, ulcers), arthralgia (44–70%; symmetric migratory, small/med joints), glomerulonephritis (50%; MPGN), neurologic (17–60%; peripheral neuropathy (polyneuropathy >mononeuritis multiplex), ↓ Hgb, ↓ plt, ↑ B-cell lymphoma risk, GI (5%; pain, HSM, ↑ LFTs). “Meltzer’s triad”: purpura, arthralgias, weakness in 25–30%.