Info

🌱 來自: hodgkin lymphoma (HL)

WHO Histologic Classification of Classical HL

Nodular sclerosis

60–80% Collagen bands; frequent mediastinal LAN; young adults; female predominance; usually stage I or II at dx Mixed cellularity 15–30% Pleomorphic; older age; male predominance; ≥50% stage III or IV at presentation; intermediate prognosis Lymphocyte rich 5% Abundant normal-appearing lymphocytes; mediastinal LAN uncommon; male predominance; good prognosis Lymphocyte depleted <1% Diffuse fibrosis and large numbers of RS cells; older, male patients; disseminated at dx; seen in HIV; worst prognosis • Nonclassical HL (5%): nodular lymphocyte predominant (NLP); involves peripheral LN 80% present in stages I–II, Rx w/ RT vs. chemoRT w/ 4-yr PFS 88% and OS 96% (JCO 2008;26:434); consider rituximab because most NLP RS cells are CD20+ Stages III–IV treated with combination chemo (see below)