Info

🌱來自: metastatic breast cancer

Workup-of-metastatic breast cancer

• H&P: Including KPS, dz-related sxs
• Labs:
  • CBC,
  • CMP,
  • consider baseline tumor markers (CEA, CA15-3, CA 27.29)
• Imaging:
  • PET-CT vs. CT C/A/P & Bone Scan (BS),
  • additional imaging for specific concerns
    • fracture → X-ray,
    • brain met → MRI,
    • equivocal staging → PET
• Bx:
  • Strongly consider for the 1st met/recurrence to document met & ER/PR/HER2 status & obtain NGS.
  • Can have discordance in receptor status between 1° & met
    • due to sampling bias,
    • Δ in tumor biology,
    • proliferation of different clone,
    • lab error

Siblings

• General management principles-of-metastatic breast cancer
• Hormone-receptor positive (HER2 negative)-of-metastatic breast cancer
• HER2 positive-of-metastatic breast cancer
• Triple negative disease
• Bone metastasis