Systemic diseases with secondary glomerular involvement

diabetes mellitus

(CJASN 2017;12:2032): nodular glomerulosclerosis (Kimmelstiel-Wilson lesion); glomerular hyperfiltration → microalbuminuria → dipstick ⊕ → nephrotic range (10–15 y). Proliferative retinopathy seen in 90% of type 1 and 60% of type 2.

amyloidosis

• AL or light-chain amyloid or AA amyloid secondary to inflammation
• systemic lupus erythematosus
  • (CJASN 2017;12:825) : typically membranous nephropathy (WHO class V)

Cryoglobulinemia

• a/w HCV, monoclonal gammopathy. Typically MPGN. (AJKD 2016;67)