Info
🌱 來自: HER2
Trastuzumab
- Mechanism: Binds to HER2
- Dosing: Loading dose 4-8 mg/kg IV, followed by 2-6 mg/kg maintenance dose IV weekly or every 21 d
- PK/PD: T1/2 ∼6-16 d
- AEs: CMP (DLT), GI upset, rash, fever, pain
- DDI: Anthracyclines (potential ↑ in cardiac tox)