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🌱 來自: Genetics and Molecular Subtypes of Diffuse large B-cell lymphoma

germinal-center B-cell

• High-grade B-cell lymphoma w/ MYC & BCL2 &/or BCL6 translocations by FISH (formerly “double-hit in DLBCL”) represent ∼8% of all DLBCL & have poorer prog.
  • Almost always GCB.
  • IHC detected “double expressors” (MYC >40% BCL2 >70%) may be assoc w/ ↓ prog (JCO 2012;30:3460).
  • Burkitt typically BCL-2(−) vs. DLBCL nearly always BCL2(+)