Info
Bone Marrow Failure Syndromes Including Aplastic Anemia and Myelodysplasia
Hypoproliferative anemia is a cardinal feature of these disorders,
differential diagnosis of pancytopenia
- frequent is pancytopenia: anemia, leukopenia, and thrombocytopenia.
- Low blood counts in marrow failure result from deficient hematopoiesis, as distinguished from blood count depression due to peripheral destruction of red cells (hemolytic anemias), platelets (idiopathic thrombocytopenic purpura [ITP] or due to splenomegaly), and granulocytes (as in the immune leukopenias).
- secondary: infection, inflammation, or cancer.
- Separation between aplastic anemia and hypocellular MDS can be particularly difficult.
- Mutations on genomic screens