Zygomycetes

接合菌門是一類真菌。其孢子分為有性及無性兩種，有性生殖為接合孢子，無性生殖為孢囊孢子；此門真菌的菌絲屬於「無隔多核」

• Epidemiology:
  • diabetes (espec. those w/ prior DKA),
  • heme malignancy,
  • neutropenia,
  • transplant,
  • chronic steroids,
  • iron overload,
  • trauma,
  • h/o voriconazole Rx or Ppx
• Clinical:
  • Rhinocerebral Mucormycosis
  • Other: pulm. (PNA w/ infarct & necrosis); cutaneous (indurated painful cellulitis ± eschar); GI (necrotic ulcers); renal (flank pain, fever).
• Treatment (high mortality):
  • 1st line is debridement + ampho.
  • Can deescalate to posaconazole or isavuconazole if improving after debridement.