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🌱來自: Management of follicular lymphoma

Histologic Transformation of follicular lymphoma

• ~3%/y risk of transformation from FL to DLBCL,

• rapid nodal enlargement & rising LDH, ± systemic symptoms

• Bx is required to diagnose transformation.

• PET may be useful in determining a site for bx.

• SUV values >10–13 suggest transformation (Ann Oncol 2009;20:508)

• Transformation to DLBCL in a previously untreated pt treated similar to de novo DLBCL

• If histologic transformation occurs after prior chemotherapy, consider consolidation w/ high dose therapy and autologous stem cell rescue in chemosensitive disease