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🌱來自: ovarian cancer

Risk factors for EOC

(Nat Rev Dis Primers 2016;2:16061) • Nulliparity, early menarche, late menopause; EOC risk ↑ 2–7% each additional ovulatory yr • Genetics: germline testing / genetics referral for all Pts (25% w/ heritable mutation), can inform Rx (eg, PARPi maintenance, JCO 2020;38:1222). 5% risk if one 1st-degree relative w/ ovarian cancer, 3.5% risk if one 2nd-degree relative (Obstet Gynecol 1992;80:700). ↑↑ risk w/ hereditary syndromes: BRCA1/2 (lifetime risk 17%/44%), Lynch syndrome (non-serous). • History of pelvic radiation, endometriosis, or obesity (risk association less clear)