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🌱 來自: Epidemiology and risk factors of small lymphocytic lymphoma

Clinical manifestations of chronic lymphocytic leukemia

• Often asx & identified by lymphocytosis on CBC; 10-20% p/w “B symptoms”
• Lymphadenopathy (80%)
  • sites of nodal areas to be examined in patients with lymphoma
• hepatosplenomegaly (50%)
• Autoimmune hemolytic anemia (AIHA) (~10%)
• thrombocytopenia (ITP) (~1-2%)
• Hypogammaglobulinemia ± neutropenia → ↑ susceptibility to infections
• Bone marrow failure in ~13%; monoclonal gammopathy in ~5%
• Aggressive Richter’s transformation in ~5% into high-grade lymphoma (poor prognosis)