Info

🌱 來自: DCIS and LCIS

DCIS

• Characteristics
  • No penetration of the basement membrane
  • Preceded by ductal atypia
  • Frequently appears as a pattern of grouped microcalcifications on mammography
  • Higher risk of subsequent ipsilateral invasive carcinoma
• ∼15-50% will progress to invasive breast CA if untreated
• Tx:
  • WE or total
  • Active surveillance, lumpectomy w/o SLN bx + RT, mastectomy ± SLN bx. ER+
  • if do WE then Tamoxifen 20mg QD x 5 years for ER (+)*
    • DCIS: Tam (premenopausal), tam or AI (postmenopausal),
      • no ↑ survival but reduces risk of ipsi- & contralateral recurrence (Cochrane 2012; Lancet 2016;387:849)
    • Primary results, NSABP B-35 _NRG Oncology: A clinical trial of anastrozole vs tamoxifen in postmenopausal patients with DCIS undergoing lumpectomy plus radiotherapy A randomized clinical trial