Immunotherapies-asthma
(NEJM 2017;377:965)
- Allergen ImmunoRx (“allergy shots”) may help if sig. allerg. component (JAMA 2016;315:1715)
- Anti-IgE (omalizumab) for uncontrolled mod-to-severe allergic asthma (w/ IgE >30) on ICS ± LABA (JAMA 2017; 318:279); ↓ exacerbations in severe asthma (Cochrane 2014;CD003559)
- Anti-IL5 (mepolizumab, reslizumab) ↓ exacerb in severe asthma (NEJM 2014;371:1189 & 1198)
- Anti-IL5Rα (benralizumab) ↓ steroid use, ↓ exac. in sev asthma w/ eos (NEJM 2017;376:2448)
- Anti-IL4Rα (dupilumab) blocks IL-4 & IL-13; ↓ exacerb in severe asthma, ↓ steroid use, ↑ FEV1 (NEJM 2018;378:2475 & 2486)
- Anti-TSLP (tezepelumab-ekko) ↓ exacerbations in severe asthma; can use in non-allergic/non-eosinophilic asthma (NEJM 2021;384:1800)