alectinib

  • Non-small Cell Lung Cancer (NSCLC)
  • Treatment of ALK-positive stage IV NSCLC (designated an orphan drug by FDA for this use).
  • Guidelines for the treatment of stage IV NSCLC in patients with driver alterations in ALK generally support use of alectinib as an option in the first-line setting and in the second-line setting following therapy with crizotinib.
  • Confirmation of ALK rearrangement necessary prior to initiation of therapy.