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Sanford Guide: HBV Natural History

Phases of Infection

  • Three phases of HBV infection.

  • Not all patients successfully make it through all 3 phases:

  • Immune tolerant phase (+HBeAg, +HBsAg, High level HBV DNA)

  • Inflammatory phase (reduction in HBV DNA; elevated transaminases)

  • Non-Replicative phase (loss of HBeAg; reduction of HBV DNA; normalization of ALT/AST).

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