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Sanford Guide: HBV Natural History

Phases of Infection

• Three phases of HBV infection.

• Not all patients successfully make it through all 3 phases:

• Immune tolerant phase (+HBeAg, +HBsAg, High level HBV DNA)

• Inflammatory phase (reduction in HBV DNA; elevated transaminases)

• Non-Replicative phase (loss of HBeAg; reduction of HBV DNA; normalization of ALT/AST).

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