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Sanford Guide: HBV Natural History
Phases of Infection
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Three phases of HBV infection.
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Not all patients successfully make it through all 3 phases:
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Immune tolerant phase (+HBeAg, +HBsAg, High level HBV DNA)
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Inflammatory phase (reduction in HBV DNA; elevated transaminases)
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Non-Replicative phase (loss of HBeAg; reduction of HBV DNA; normalization of ALT/AST).