Etiologies- cirrhosis

• Alcohol, toxins (eg, arsenic)

• Nonalcoholic fatty liver disease (NAFLD) is the cause of most “cryptogenic cirrhosis”

• Viral hepatitis: chronic HBV, HCV, HDV infection

• Autoimmune hepatitis: ♀, ↑ IgG, ⊕ ANA, ASMA, anti-LKM-1, anti-LC1

• Metabolic diseases: hemochromatosis, Wilson disease, α1-AT deficiency

• Biliary tract diseases: primary biliary cholangitis, secondary biliary cirrhosis (calculus, neoplasm, stricture, biliary atresia), primary sclerosing cholangitis

• Vascular diseases: Budd-Chiari syndrome, R-sided CHF, constrictive pericarditis, SOS

• Medications: amiodarone, methotrexate, vitamin A, valproic acid, isoniazid