Info
🌱 來自: gout
Definition and epidemiology of gout
(Rheumatology 2018;58:27; Lancet 2021;397:1843)
- Humans lack enzyme (uricase) to metabolize urate (end-product of purine metabolism)
- MSU crystal deposition promotes inflammation in joints and peri-articular tissue;
- Prev >1/30 American adults, ♂ >♀;
- peak incidence 5th decade;
- most common inflamm arthritis in ♂ over 30 y;
- rare in premenopausal ♀ (estrogens ↑ renal urate excretion)