Hypoparathyroidism

(NEJM 2019;380:1738; JCEM 2020;105:1722)

• Control of Mineral Homeostasis by Parathyroid Hormone and the Calcium-Sensing Receptor.
• Iatrogenic (s/p thyroidectomy, rarely after parathyroidectomy);
• sporadic;
• familial (APS1, activating Ca-sensing receptor mutations; see page 7-2);
• Wilson’s, hemochromatosis;
• hypoMg (↓ secretion and effect);
• activating Ca-sensing receptor autoAb