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🌱 created from: bcma_in_mm

bcma

B-cell maturation antigen (BCMA) has emerged as a promising target for MM therapies. Currently, the three most common treatment modalities for targeting BCMA are bispecific antibody constructs including BiTE® (bispecific T-cell engager) immuno-oncology therapies, antibody–drug conjugates (ADCs), and chimeric antigen receptor (CAR)-modified T-cell therapy. In this review, we provide an overview of therapies from these classes that have presented or published clinical data, including the BiTE® molecule AMG 420, the ADC GSK2857916, and several CAR T-cell therapies including NIH CAR-BCMA, bb2121, and LCAR-B38M.