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Epidemiology of metastatic breast cancer

  • 6% of breast CA is met at dx (SEER Cancer Stats Review 1975–2013)
  • HR+/HER2- ~60%, HR-/HER2+ ~10%, HR+/HER2+ ~15%, TNBC ~15%
  • Risk of BC recurrence after local Rx greatest in 1st 3 yrs but persists for decades, w/HER2+/TNBC pts at highest risk for early recurrence & ER+ for late (JCO 2016;34:927)
  • Most common met sites: Lung (esp TNBC), bone (esp ER+), liver, & adrenal gland