Etiology-mitral-regurgitation

• Valve disease (43%): rheumatic (usually mixed AS/AR + MV disease); bicuspid AoV (natural hx: ⅓→ normal, ⅓→ AS, ⅙→ AR, ⅙→ endocarditis → AR); infective endocarditis; valvulitis (RA, SLE, certain anorectics & serotonergics, XRT)
• Root disease (57%): HTN, aortic aneurysm/dissection, annuloaortic ectasia (ie, Marfan), aortic inflammation (GCA, Takayasu’s, ankylosing spond., reactive arthritis, syphilis)